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Buy MK-677 Ibutamoren

MK-677, also known as Ibutamoren, is a growth hormone secretagogue that is known for its potential to stimulate the secretion of growth hormone and IGF-1. Unlike traditional anabolic steroids, MK-677 works by targeting the ghrelin receptor, leading to increased growth hormone levels in the body. This can result in various benefits such as enhanced muscle growth, improved recovery, and potentially even fat loss. 

MK-677 Liquid Droppers

MK-677 Ibutamoren Products

Depending on the objectives of your research PharmaGrade Store offers an extensive range of MK-677 Ibutamoren products for laboratory research use:

Buy MK-677 Ibutamoren for Research

MK-677, a selective agonist of the ghrelin receptor, functions as a powerful growth hormone secretagogue by mimicking the action of the endogenous hormone ghrelin. Upon binding to the ghrelin receptor, MK-677 stimulates the release of growth hormone (GH) from the pituitary gland. This leads to an increase in circulating GH levels, subsequently triggering the production of insulin-like growth factor 1 (IGF-1) in the liver and other tissues [1].

The elevated levels of GH and IGF-1 play crucial roles in various physiological processes, including promoting muscle growth, enhancing bone density, lean body mass, appetite, improving strength, aiding in fat loss, and potentially regulating sleep patterns including rapid eye movement.

Through its mechanism of action, MK-677 showcases potential benefits for overall wellness, performance enhancement, and addressing certain age-related conditions where declines in GH and IGF-1 levels may play a role, for example muscle wasting disorders and osteopetrosis [2]. 

Benefits of MK-677

Clinical investigations have suggested that the research chemical MK-677 Ibutamoren could have the following benefits:

  • Promotes muscle growth – MK-677 stimulates the secretion of growth hormone and insulin-like growth factor 1 (IGF-1), which are essential factors in enhancing muscle protein synthesis and hypertrophy [5].
  • Increase strength – the elevation of GH can improve strength and endurance whilst reducing recovery time.
  • Improve bone density – MK-677 can improve bone density by stimulating bone turnover and increasing mineralization, as demonstrated in scientific studies, highlighting its potential benefits for bone health [1].
  • Burns fat – MK-677 can burn fat by boosting metabolism and promoting the utilization of stored fat for energy, a mechanism attributed to its ability to increase growth hormone levels and lean muscle mass supporting a favourable body composition. 
  • Enhance sleep quality – MK-677 can promote sleep by enhancing the quality of sleep through its impact on the regulation of the sleep-wake cycle and potentially increasing REM sleep duration [6].

MK-677 Clinical Studies

Scientific studies have delved into the efficacy of MK-677, showcasing its potential in various realms. For instance, a study published in “The Journal of Clinical Endocrinology & Metabolism” demonstrated that MK-677 significantly boosted GH and IGF-1 levels in healthy adults [3].

Another study in “The Journal of Biological Chemistry” highlighted how MK-677 could enhance bone turnover and increase bone mineral density [4].

These findings underscore the scientific basis behind the mechanism of action of MK-677 and its future potential applications in promoting overall wellness and performance.

Ibutamoren MK-677 Specifications:

View PharmaGrade Store MK-677 Ibutamoren HPLC Certificate here.

Molecular Formula:C27H36N4O5S

Molecular Weight: 528.662 g/mol

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MK677 RAD140 Sarm Blend Capsules

MK677 & RAD140 Blend Capsules

Combining MK-677 and RAD140 SARMs has proven in studies to synergistically enhance muscle growth, strength gains, and overall performance by leveraging their individual mechanisms of action. The anabolic effects of RAD140, known for its selectivity in targeting androgen receptors, complemented by MK-677’s ability to boost growth hormone levels, can lead to a potent combination for achieving significant improvements in muscle mass and physical capabilities.

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MK677 GW-501516 Stack

MK-677 & GW501516 SARM Stack

Combining MK-677 and GW501516 SARMs could with further research offer a comprehensive approach to fitness and performance enhancing, with MK-677 supporting muscle growth and recovery through increased growth hormone levels, while GW501516, also known as cardarine, enhances endurance and fat metabolism by activating the PPAR-delta pathway. 

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Frequently Asked Questions about MK-677

Is MK-677 Safe?

Although not yet approved worldwide, MK-677 is generally considered safe when used as directed and under medical supervision. However, like any supplement or medication, it may have potential side effects and interactions, especially if used inappropriately or without dosage proper guidance. It’s important to consult with a healthcare provider before starting MK-677 to assess individual health considerations and ensure its safe use and free of adverse reactions.

Will MK677 help with fat loss?

MK-677 may indirectly support fat loss through its potential effects on increasing metabolism and promoting muscle growth, which can contribute to overall body composition improvements. Whilst fat loss is not its main benefit, the metabolic rate enhancements and changes in body composition associated with MK-677 could potentially aid in reducing body fat over time when combined with a balanced diet and regular exercise regimen.

Could MK-677 be used to treat osteoperosis?

MK-677 shows promise in potentially aiding osteoporosis treatment by stimulating the production of insulin-like growth factor 1 (IGF-1), which plays a crucial role in bone remodeling and mineralization. The increased levels of IGF-1 resulting from MK-677 use may support bone density and strength, suggesting a potential benefit for individuals with osteoporosis [1]. However, further research is needed to fully understand the efficacy and safety of MK-677 specifically for osteoporosis treatment.

Can MK-677 improve libido?

Research has found that MK-677 may have indirect effects on libido by potentially enhancing overall well-being, energy levels, and muscle mass, which can positively influence sexual health and performance. While not primarily marketed as a libido-enhancing supplement, some individuals may experience improvements in libido as a result of the metabolic and hormonal changes associated with MK-677 use.

Further Reading:


Exploring the Best Peptides for Beginners

Beginner Peptides

Discover what research suggests are the best peptides for beginners. Including why MK-677 Ibutamoren is sometimes considered to be a peptide rather than a SARM compound. 

Find out which peptides are considered to have a better safety profile, and which ones are yet to be approved by the FDA.

Read more here.

Does MK-677 Affect Testosterone?


While MK-677 is known for its potential to increase growth hormone levels, its impact on testosterone is a topic of interest. We explore the existing research, discuss how MK-677 may influence testosterone production indirectly, and provide insights into considerations for individuals looking to understand the effects of MK-677.

Understand more about the link between MK-677 and Testosterone levels.

Scientific Research:

[1] Bennett KA, Langmead CJ, Wise A, Milligan G. Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. Mol Pharmacol. 2009 Oct;76(4):802-11.

[2] Murphy MG, Weiss S, McClung M, Schnitzer T, Cerchio K, Connor J, Krupa D, Gertz BJ; MK-677/Alendronate Study Group. Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women. J Clin Endocrinol Metab. 2001 Mar;86(3):1116-25.

[3] M. G. Murphy, L. M. Plunkett, B. J. Gertz, W. He, J. Wittreich, W. M. Polvino, D. R. Clemmons, MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism, The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 2, 1 February 1998, Pages 320–325.

[4] Svensson J, Ohlsson C, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Baylink D, Mohan S, Bengtsson BA. Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males. J Bone Miner Res. 1998 Jul;13(7):1158-66. 

[5] Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE Jr, Clasey JL, Heymsfield SB, Bach MA, Vance ML, Thorner MO. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008 Nov 4;149(9):601-11.

[6] Georges Copinschi; Rachel Leproult; Anne Van Onderbergen; et al. Prolonged Oral Treatment with MK-677, a Novel Growth Hormone Secretagogue, Improves Sleep Quality in Man, Neuroendocrinology (1997) 66 (4): 278–286.

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