Melanotan 1 resembles alpha-MSH (Melanotan 2). Alpha-MSH affects skin and hair pigment-producing melanocytes. This is mediated by melanocortin receptor 1. Alpha-MSH agonists melanocortin 1, 3, 4, and 5. Melanotan 1 differed from alpha-MSH (Melanotan 2) by one amino acid. Melanocortin receptors and their effects were little understood then. Melanotan 1 induces pigmentation and enhances sexual arousal, appetite, and basal metabolism. Melanotan 1 and other melanocortin-binding proteins helped scientists comprehend the signalling cascade.
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