Melanotan 1 Peptide Vial
Melanotan 1 is a peptide hormone alpha-MSH (α-melanocyte stimulating hormone) that induces skin tanning. In October 2014, Melanotan 1 was approved in Europe for the treatment of EPP (erythropoietic protoporphyria).
What Are the Features of Melanotan 1 ?
Melanotan 1 provides prophylactic treatment by encouraging melanin production, which acts as a filter on ultraviolet impact over your skin.
EPP (Erythropoietic protoporphyria) – This is an autosomal recessive metabolic disorder that’s characterised by painful photosensitivity, which is typically present in childhood, with crying after first sunlight exposure. With repeated sunlight exposure, the swelling and redness may lead to thickened facial skin. Severe neuropathic pain may last for days. Cholestatic hepatitis and gallstones occur in 5 per cent of patients. Two multicenter, randomised, double-blind experiments were performed in 167 people with erythropoietic protoporphyria in the USA and EU. Patients received bioresorbable implants of Melanotan 1 subcutaneously or placebo on days 120, 60 and 0. In the longer Additional trial in Europe, additional insertions were administered.
In both trials, Research analysing have actually discovered it could was reported that the primary endpoint of the patient experiencing pain-free duration was longer in Melanotan 1 recipients. Also, phototoxic reactions were significantly fewer plus the quality of life improved significantly in the patients who received Melanotan 1.
Photodynamic Therapy (PDT) – Photodynamic therapy is a cancer therapy that uses a laser together with a drug that’s sensitive to light to kill cancer cells. However, this therapy weakens the photosensitivity of eyes and skin to any light. Melanotan 1 Study studies have actually discovered it could prevent the phototoxicity associated with PDT.
Role of Melanotan 1 in Vitiligo Treatment – Melanotan 1 is an emerging method of treating vitiligo that’s long-lasting. Analysis studies have found it could binds to the MC1R (melanocortin-1 receptor) and starts to stimulate melanogenesis and melanocyte proliferation. The basis of this treatment is typically the understanding that people with this condition show defects in their melanocortin system. This manifests as a decline in the levels of the alpha-melanocyte stimulating hormone in both skin lesions and systemic circulation. A trial that involved 55 patients who received Melanotan 1 together with NB-UVB revealed that repigmentation of facial plus upper extremity lesions was faster when compared to patients who used NB-UVB alone.
Solar Urticaria – Solar urticaria, also know as SU, is a skin disorder that’s marked by a severe allergic response after exposure to sun or UV. Symptoms Research studies have actually found it could be systematic, like headaches, breathing difficulty and anaphylaxis. Immediate localised reactions may vary from swelling of soft tissues to erupting flares and characteristic ‘wheal’ formation on exposed skin sites. A study that was conducted in patients with solar urticaria showed that those who received Melanotan 1, the tolerance of their skin to the light of different intensities and wavelengths was increased.
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